Volume 5, Number 5

eDIRC Update for Friday, May 4, 2007

Dear [[FirstName]]:

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In this edition:

  1. DIRC/OPA News
  2. Canadian Adverse Reaction Newsletter
  3. Health Canada Warnings and Advisories
  4. Online Publications
  5. News
  6. DIRC Values Your Feedback


1. DIRC/OPA News
DIRC Provides Clinical Support to Ontario Pharmacists to Support Professional Services
To support the launch of professional services in Ontario, DIRC is now providing support to pharmacists in implementing the Meds Check medication review program. This support is funded by the Ministry of Health and Long-Term and is available to all Ontario pharmacists. DIRC will provide clinical support to help pharmacists implement medication review services.  (Note: If you are not a DIRC subscriber, services provided by DIRC will be limited to support in implementing the protocol and program only - this service does not replace your regular drug information service subscription.)

The following changes were made to the Personal Medication Review Forms based on pharmacist feedback and ease of implementation to practice:

Form 1: Patient Background Form
·    Removed Doctor field, Doctor # field, Health Card # field, Reason for Review column
·    Removed alcohol and tobacco categories, and two Background Information questions
·    Added Meds Check Patient Criteria           

Form 2: Patient Medication History Form
·    Added Patient Adherence column to Table 1 and Table 2
·    Renamed column I in Table 2 as “Expiry Date”

Form 3: Medication Review: Action Plan
·    Removed Health Card Number and Pharmacist Signature fields

Form 4: Personal Medication Record
·    Removed Stop Date column and Updated field
·    Switched Medication Brand (Generic) column with Start Date column
·    Renamed Family or Primary Physician as “Primary Physician”
·    Added Date of Last Meds Check field

Form 5: Physician Letter
·    Simplified information required on letter
·    Removed Patient Information box and Contact Number at bottom
·    Reworded first check box as “No medication adherence issues”

Bag Stuffer:
·    Reworded phrasing to state “this service is covered by the provincial drug plan”

Data Collection Form
·    Modified to reflect changes in forms
·    Elaborated on potential issues that could be identified in columns of Form 2
 
For more information on pharmacist professional services in Ontario, visit the new OntarioRph.ca website. For rapid access to DIRC's tools and protocol, visit the DIRC website. For clinical support, contact DIRC by email or by phone at (800) 268-8058 and press "2" at the first prompt.

Obesity Certificate Program
The Canadian Obesity Network (CON) and OPA have partnered to bring pharmacists a one-day obesity education program that will be held in various locations nationally.  Delivered in a combination of lecture and case-based learning styles, pharmacists will gain a better understanding of obesity and be well-equipped to provide practical information on the prevention and management to their patients.  Topics covered will include an introduction to obesity, pathophysiology, evaluation, and various pharmacological and non-pharmacological treatment strategies that follow the new 2006 Canadian Clinical Practice Guidelines on the Management and Prevention of Obesity.

To be added to our notification list for more information as it becomes available, click here.

Call for Abstracts: OPA Annual Conference: September 7-8, 2007
Have you developed an innovative program, service or intervention that is relevant to practising pharmacists? Are you interested in profiling yourself, your pharmacy team and pharmacy while building your CV? Consider submitting an abstract for consideration for the 2007 OPA conference.   Both poster presentations and oral presentations will be accepted. Abstracts may be submitted online at www.opatoday.com up until May 15, 2007. Notification of accepted submissions will take place by June 29, 2007.  Full details are available on the OPA website.

DIRC Speaker Registry

Do you have expertise in a particular area of practice?
Are you interested in public speaking?
Do you have innovative ideas for CE topics?
DIRC is seeking speakers on various educational topics for presentations across Canada! If you answered "Yes" to these questions please click on the link and apply to become part of the Drug Information and Research Centre (DIRC)'s speaker registry.

Staff Announcements
DIRC is pleased to announce that Shao Lee, BScPhm, MBA is joining the DIRC team as a full-time Drug Information Pharmacist. Shao's work experience has included retail pharmacy manager, business research analyst/consultant positions, and a number of roles at Janssen-Ortho, including marketing associate, medical sales representative, product specialist, and most recently, CHE business manager (pain/GI). Shao also continues to work part-time in community pharmacy.
 
Shao joins a team of skilled health professionals at DIRC dedicated to improving the appropriate use of medications. For more information, visit DIRC staff profiles.


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2. Canadian Adverse Reaction Newsletter
In the April issue:

Quetiapine - Pancreatitis and Thrombocytopenia
There have been 9 and 11 reported cases of pancreatitis and thrombocytopenia, respectively, possibly associated with quetiapine use. These cases have been reported between the end of December 1997 until October 2006. These two adverse reactions are not listed in the Canadian product monograph.

Telithromycin - Toxic Epidermal Necrolysis
A woman who completed a 12 day course of telithromycin was diagnosed with toxic epidermal necrolysis after starting a second course two days later. She first experienced a rash which progressed to reddening of the eyes and skin as well as swelling of the face and lips. Eventually, the skin was peeling from her head to her thighs, involving more than 50% of her body. Acute respiratory distress syndrome ensued, requiring intubation. The patient recovered after a 4 week hospital stay and was discharged with scars on her body and face.

Bitter Orange/Synephrine - Cardiovascular Adverse Reactions
Products containing synephrine, an
α1-agonist, are not authorized for sale in Canada. Products containing synephrine are used for weight loss. There have been 31 reported cases of cardiovascular adverse events possibly associated with the use of bitter orange or synephrine from January 1998 until October 2006 including 1 case of myocardial infarction. Certain patients with predisposing medical conditions should not use products containing this agent.  These populations include individuals with thyroid disease, heart conditions, hypertension, CNS disorders, glaucoma, pheochromocytoma or enlarged prostate. Individuals taking thyroid hormones, monoamine oxidase inhibitors or medications to control heart rate or blood pressure should also not consume these products.

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3. Health Canada Warnings and Advisories
Erythropoeisis-stimulating agents, darbepoetin (Araesp) and epoetin alfa (Eprex), should not be prescribed for cancer patients who do not have anemia associated with chemotherapy.

Consumers are advised not to use FiberChoice plus Multivitamins, a fibre supplement originating from the United States. This product contains an undeclared ingredient, fish gelatin. This may provoke an allergic response in individuals with allergies to seafood.

Consumers are advised not to use Eden Herbal Formulations Serenity Pills II, a herbal sleep supplement.  This product has been found to contain the benzodiazepine estazolam.  The product is not authorized for sale in Canada but was previously distributed in Alberta.

Consumers are advised not to use Lanmei Keili Ji, a cold, flu and cough product. This product originates from China and has been found to contain the antidiabetic agent gliclazide. This product is not authorized for sale in Canada but may have been purchased abroad or through the internet.

Consumers are advised not to use V.MAX, Rhino Max (Rhino V Max). This product originates from the United States and has been found to contain aminotadalafil, an analogue of tadalafil. This product is not authorized for sale in Canada but may have been purchased abroad or through the internet.

Consumers are advised that certain lots of Salivart Oral Moisturizer may be contaminated with mould or yeast. Only one lot of the affected product has been distributed in Canada. The lot number is 06BB002, with an expiration date of 06-08.

Health Canada is reviewing the association between the use of pergolide (Permax) and cardiac valvulopathy following its withdrawal from the market in the United States. Two studies published in January 2007 concerning the association of the use of pergolide with the risk of cardiac valve abnormalities are being reviewed by Health Canada.

There have been several cases of self harm, abnormal or suicidal behaviour reported in pediatric patients taking oseltamivir (Tamiflu) in Japan. No such cases have been reported in Canada. The causailty between the use of the drug and self harm has not been established. Complications of influenza may lead to changes in mental state and contribute to this behaviour.

Consumers are advised not to use the natural health product XOX For Men and Vigorect Oral Gel Shooter. These products has been found to contain tadalafil. These products are not authorized for sale in Canada however they may have been imported and found on the Canadian market.

There have been reports of acute renal failure that may be possibly associated with the use of deferasirox (Exjade). Serum creatinine should be assessed twice before patients receive treatment with deferasirox. Serum creatinine should be monitored weekly for the first month after initiating treatment and monthly thereafter. There have also been cases of cytopenia reported in patients treated with deferasirox. The association between the occurrence of cytopenia and the use of deferasirox is unknown.

Consumers are advised not to use Miaozi Slimming Capsules or Lexscl Fat Rapid Loss capsules. These products are not authorized for sale in Canada but may have been purchased abroad or through the internet. Both products have been found to contain sibutramine.

Consumers are advised not to use certain lots of ReNu MultiPlus contact lens solution manufactured by Bausch and Lomb. Affected lots are designated GC6038 and GC6052. The Drug Identification Number (DIN) for this product is 02230538. The affected lots have been found to contain higher levels of iron. This may lead to increased risk of infection and decreased product effectiveness as a contact lens cleanser.

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4. Online Publications

The March 2007 issue of Canadian Family Physician is available  and includes articles on:

Safety of rheumatoid arthritis medications in pregnancy

Do derivatives of panax ginseng prevent colds?


The March 15, 2007 issue of American Family Physician is available and includes articles on:

Diagnosis and Treatment of Impetigo

Infertility



The April 10th issue of CMAJ is available:

Management of hypothyroidism during pregnancy

Synopsis of the 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children

2006 Canadian clinical practice Guidelines on the management and prevention of obesity in adults and children

Hypertriglyceridemia: its etiology, effects and treatment    


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5. News
Teaming Up For Musculoskeletal (MSK) Care: An Interprofessional Approach
The two-day conference will provide the participant with an enhanced learning experience that is relevant to current clinical practice and will assist in developing an interprofessional network. The program is developed through the Centre for Effective Practice at the Department of Family & Community Medicine, University of Toronto, in conjunction with university-appointed faculty. The unique needs of primary care practitioners will be central to the course curriculum so that the common educational gaps in MSK knowledge can be bridged. For more information please email  msk@effectivepractice.org, call 416.619.0089 or download the conference brochure at
www.effectivepractice.org (located on the homepage).
Dates:  June 8 & 9, 2007
Location: Toronto Marriott Downtown Eaton Centre Hotel (525 Bay Street, Toronto)


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6. DIRC Values Your Feedback
DIRC strives for 100% client satisfaction with every call or inquiry. If you have any general questions or comments about DIRC's services, please contact Mandy De Jong, Senior Manager, Quality Assurance (acting), at (416) 385-2440 x 2205, or Scott Gavura, DIRC Director, at (416) 385-2440 x 2222.

If you have received information via fax, you may fill out a satisfaction survey at the DIRC website (have your reference number from the fax cover sheet handy).

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Your feedback on the bulletin and on DIRC's services is welcomed.


Sincerely,


Mandy De Jong, Senior Manager, Quality Assurance (acting)
Leam Tang, Drug Information Pharmacist
Editors, eDIRC

Contacting DIRC:
Telephone: (800) 268-8058 or (416) 385-DIRC [3472]
Fax: (416) 385-2442
E-mail: help@dirc.ca
Web: www.dirc.ca
Mail:
375 University Avenue, Suite 800
Toronto, ON
M5G 2J5

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